Overview
Uterine fibroids are common growths of the uterus. Uterine fibroids are not cancer, and they almost never turn into cancer. Fibroids vary in number and size. You can have a single fibroid or more than one and the size can be small or very large. They can make a person look pregnant.
Many people have uterine fibroids sometime during their lives. But you might not know you have them, because they often cause no symptoms.
Many people who have uterine fibroids don't have any symptoms. In those who do, symptoms can be influenced by the location, size and number of fibroids.
The most common symptoms of uterine fibroids include:
Rarely, a fibroid can cause sudden, serious pain when it outgrows its blood supply and starts to die.
Often, fibroids are grouped by their location. Intramural fibroids grow within the muscular wall of the uterus. Submucosal fibroids bulge into the uterine cavity. Subserosal fibroids form on the outside of the uterus.
See your health care provider if you have:
The exact cause of uterine fibroids isn't clear. But these factors may play roles:
Hormones. Estrogen and progesterone seem to help fibroids grow.Fibroids tend to shrink after menopause due to a drop in hormone levels.
Research suggests that uterine fibroids may develop from a stem cell in the smooth muscular tissue of the uterus. A single cell divides over and over. In time it turns into a firm, rubbery mass distinct from nearby tissue.
Fibroids that form during pregnancy can shrink or go away after pregnancy, as the uterus goes back to its usual size.
There are few known risk factors for uterine fibroids, other than being a person of reproductive age. These include:
Uterine fibroids often aren't dangerous. But they can cause pain, and they may lead to complications. These include a drop in red blood cells called anemia. That condition can cause fatigue from heavy blood loss. If you bleed heavily during your period, your doctor may tell you to take an iron supplement to prevent or help manage anemia. Sometimes, a person with anemia needs to receive blood from a donor, called a transfusion, due to blood loss.
Often, fibroids don't interfere with getting pregnant. But some fibroids — especially the submucosal kind — could cause infertility or pregnancy loss.
Fibroids also may raise the risk of certain pregnancy complications. These include:
Researchers continue to study the causes of fibroid tumors. More research is needed on how to prevent them, though. It might not be possible to prevent uterine fibroids. But only a small percentage of these tumors need treatment.
You might be able to lower your fibroid risk with healthy lifestyle changes. Try to stay at a healthy weight. Get regular exercise. And eat a balanced diet with plenty of fruits and vegetables.
Some research suggests that birth control pills or long-acting progestin-only contraceptives may lower the risk of fibroids. But using birth control pills before the age of 16 may be linked with a higher risk.
Introduction
Down syndrome (DS) is a genetic disorder caused by the presence of all or part of the third copy of chromosome 21. It is typically associated with physical growth delays, characteristic facial features, and mild to moderate intellectual disability.
Manifestations and disabilities of Down syndrome
Those with Down syndrome nearly always have physical and intellectual disabilities. As adults, their mental abilities are typically similar to those of an 8- or 9-year-old. They also typically have a poor immune function and generally reach developmental milestones at a later age. They have an increased risk of a number of other health problems, including congenital heart disease, leukemia, thyroid disorders, and mental illness.
Physical characteristics
People with Down syndrome may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and large tongue. Instability of the atlantoaxial joint occurs in about 20% and may lead to spinal cord injury in 1-2%.
Growth in height is slower, resulting in adults who tend to have short stature—the average height for men is 154 cm (5 ft 1 in) and for women is 142 cm (4 ft 8 in). Individuals with Down syndrome are at increased risk for obesity as they age.
Mental subnormality in Down syndrome
Most individuals with Down syndrome have mild (IQ: 50-70) or moderate (IQ: 35-50) intellectual disability with some cases having severe (IQ: 20-35) difficulties.
Many developmental milestones are delayed.
Commonly, individuals with Down syndrome have better language understanding than the ability to speak. They typically do fairly well with social skills.
Behavior problems are not generally as great an issue as in other syndromes associated with intellectual disability. While generally happy, symptoms of depression and anxiety may develop in early adulthood.
Other manifestations
Children and adults with Down syndrome are at increased risk of seizures Many (15%) who live 40 years or longer develop dementia of the Alzheimer's type.
Hearing and vision disorders occur in more than half of people with Down syndrome. Even a mild degree of hearing loss can have negative consequences for speech, language understanding, and academics.
The rate of congenital heart disease in newborns with Down syndrome is around 40%.
Cancers of the blood are 10 to 15 times more common in children with Down syndrome.
Low thyroid hormone levels occur in almost half of all individuals with Down syndrome. This is treatable with oral thyroxine. Constipation also occurs in nearly half of people with Down syndrome and may result in changes in behavior.
Males with Down syndrome usually do not father children, while females have lower rates of fertility relative to those who are unaffected.
Screening
Guidelines recommend screening for Down syndrome to be offered to all pregnant women, regardless of age. If screening is positive, invasive tests like amniocentesis or chorionic villous sampling are required to confirm the diagnosis. Screening in both the first and second trimesters is better than just screening in the first trimester.
Several blood markers can be measured to predict the risk of Down syndrome during the first or second trimester along with ultrasound results.
The diagnosis can often be suspected based on the child's physical appearance at birth. An analysis of the child's chromosomes is needed to confirm the diagnosis, and to determine if a translocation is present, as this may help determine the risk of the child's parents having further children with Down syndrome.
Management
Efforts such as early childhood intervention, screening for common problems, medical treatment where indicated, a good family environment, and work-related training can improve the development of children with Down syndrome. Education and proper care can improve the quality of life. Typical childhood vaccinations are recommended.
Health screening
Hearing at 6 months, 12 months, then yearly and in adults every 3-5 years
Thyroid test at 6 months, then yearly
Eyes at 6 months, then yearly
Dental check-up at 2 years, then yearly
Neck X-rays - Between 3 and 5 years of age
Heart - electrocardiogram and ultrasound of the heart at birth.
Surgical repair of heart problems may be required as early as three months of age.
Cognitive development
Hearing aids or other amplification devices can be useful for language learning in those with hearing loss. Speech therapy may be useful and is recommended to be started around 9 months of age. As those with Down's typically have good hand-eye coordination, learning sign language may be possible. Education programs before reaching school age may be useful. School-age children with Down syndrome may benefit from inclusive education (whereby students of differing abilities are placed in classes with their peers of the same age), provided some adjustments are made to the curriculum.
Outlook
Although many Down syndrome children have physical and mental limitations, they can live independent and productive lives well into adulthood. The level of intellectual disability varies but is usually moderate. Adults with Down syndrome have an increased risk of dementia.
Severe heart problems or certain types of leukemia can cause early death in patients with Down syndrome.
Prevention
A woman's risk of having a child with Down syndrome increases as she gets older. The risk is significantly higher among women age 35 and older. Hence, all pregnant women, especially those older than 35 years should be screened for Down syndrome in the baby.
Couples who already have a baby with Down syndrome have an increased risk of having another baby with the condition and need genetic counseling. Tests can be done on a fetus during the first few months of pregnancy to check for Down syndrome.
FAQs
Q Is infertility just a woman’s problem?
No, infertility is not only due to female factors. Both women and men can have problems that cause infertility. About one-third of infertility cases are caused by female factors. Another one third of infertility problems are due to male factors. The other cases arecaused by a combination of male and female factors or by unexplained problems.
Q What factors increase a woman’s risk of infertility?
Female age – we know that after the age of 35, the chances of falling pregnant naturally start to decline exponentially and egg quality decreases substantially. Smoking and excessive alcohol use can have a negative impact by damaging the egg quality.
Lifestyle factors such as stress, poor diet and excessive athletic training can increase the chances of infertility.
Being overweight or underweight, as this will affect ovulation.
Q How does age affect a woman’s ability to have children?
Due to many women waiting until their 30s and 40s to have children today, we are seeing an increased number of patients who require assistance to fall pregnant. Science has well established that aging decreases a woman’s chances of having a baby due to the following reasons:
Egg quality decreases with age (at age 40, 3 in every 4 eggs will be abnormal, despite regularovulation).
Egg reserve gets less with age.
Miscarriages are more likely due to increased DNA damage, leading to abnormal eggs.
What is Endometriosis?
Endometriosis is a condition where tissue similar to the lining of the womb (endometrium) is found outside the womb. About 1 out of 10 women of childbearing age may have endometriosis and symptoms typically present between the ages of 25 and 40.
Endometriosis tissue are responsive to hormones produced by the ovary. When the lining of the womb thickens and grows each month and breaks down as a period in response to the ovarian hormones, endometriosis tissue does the same and this cause accumulation of blood and inflammatory material near the endometriosis tissue. Endometriosis is not a malignant disease (not cancerous), and disappears after menopause.
What Causes Endometriosis?
The exact cause of endometriosis is not known. There are many theories that includes, backflow of tissue shed with menses in to the pelvis through the fallopian tubes (retrograde menstruation); or a genetic cause because in some women it is found in other close relatives (mother, aunts, daughters etc.).
What are the symptoms?
Some women who have endometriosis have no symptoms; however common symptoms include:
Pain before the period starts
Pain during periods (dysmenorrhoea)
Pain during intercourse (dyspareunia)
Heavy periods (menorrhagia)
Infertility – difficulty getting pregnant
Uncommon symptoms include pain when bowels have opened, pain in the lower
abdomen when passing urine and blood in the urine or faeces. Very rarely, patches of endometriosis can occur in other sites of the body. This can cause unusual pains in various parts of the body that occur at the same time as period pains.
How is Endometriosis Diagnosed?
There are no blood tests used in the clinic to diagnose endometriosis.
Ultrasound scans and MRI scans can suggest a diagnosis of particular types of endometriosis, such as endometriosis cysts in the ovaries or severe endometriosis involving bowels, but may not always diagnose the common form of mild endometriosis.
Definite diagnosis of endometriosis can be made by examining the pelvis during surgery (usually laparoscopy or key hole surgery), when the spots/patches/ ovarian cysts made by endometriosis tissues are seen and can be biopsied and tested in the lab.
Active areas of endometriosis can be seen as red vesicles (blisters), or blue spots where altered blood collected in these and white or brown patches represent older or inactive endometriosis. Extensive adhesions, lumps of endometriosis tissue (nodules) and endometrioma (endometriosis cysts on the ovaries) can also be seen during a laparoscopy surgery carried out to diagnose the disease.
How does Endometriosis Progress?
The natural cause of endometriosis is currently unknown. The available limited evidence from research studies suggest that untreated endometriosis may get better in 3 out of 10 women; becomes worse in 3 out of 10 women; whilst remain unchanged in the remaining women without treatment.
At present there are no curative treatment for endometriosis or associated symptoms, and when offering treatments to women with endometriosis, doctors cannot predict who are likely to have their endometriosis worsened if untreated. Even with treatment,
endometriosis can recur, but some women with severe untreated endometriosis may be at risk of complications such as obstruction or blockage of the ureter (the tube between the kidney and bladder). These issues need to be considered when choosing the treatment options.
Why & How is Endometriosis Staged?
The amount of the endometriosis tissue present in the pelvis is usually described by doctors in a certain way to standardise their assessment for doctors and patients to consider surgical treatment and other treatment options. Many doctors use the classification provided by the American Society for Reproductive Medicine to assess the severity and extent of the disease. This system gives points based on where the endometriosis tissue is and how deep beneath the surface they extends to, so it can assist in staging the extent of endometriosis.
How is Endometriosis Treated?
There is no known cure for endometriosis; the aim of the treatment is to manage and improve the symptoms associated with the condition. This can be done medically and / or surgically. There are some lifestyle changes that may also help to alleviate symptoms.
Medical Treatment
Medical treatment is simulating the hormonal background of either pregnancy or menopause, because symptoms associated with endometriosis, settle during those times. The available treatments are;
The combined oral contraceptive pill (OCP) or progestogen only pill (POP) (to mimic pregnancy). These treatments will reduce the number of menses so will reduce the pain and symptoms associated with endometriosis.
Gonadotrophin releasing hormones (GNRH)(to mimic menopause) this treatment is usually given for 6 months, during which you won’t have periods. Endometriosis tissue is expected to dry out when you are on treatment. The menopause symptoms that some women experience can be reduced by using a low dose hormone replacement therapy – or add-back as necessary (although this is a hormone based treatment is does not reduce the efficiency of the medication). This treatment offers temporary relief but some women experience benefit for many months/years even after treatment. Since using this treatment for long periods can make bones thin (osteoporosis) it is not used for longer periods.
Surgical Treatment
Endometriosis can be surgically removed and this is favourably done using key-hole surgery called a laparoscopy (see separate Laparoscopy patient information leaflet). Laparoscopy may provide symptom control and may improve fertility in some women. For mild endometriosis in particular, surgical excision does not provide any additional benefit over medical therapy in symptom relief or return of symptoms after treatment.
Occasionally bigger operations are offered to separate adhesions and remove endometriosis cysts from ovaries. The women who need extensive and complex surgeries for endometriosis should be done in specialist centres, where they are discussed at
regular multidisciplinary team meetings involving other specialist than gynaecologists (bowel surgeons, urologists, radiologists and pain specialists) and these specialists will decide that final surgery may need to be done by the appropriate team of surgeons with specific skills. As a last resort removal of the uterus, cervix, fallopian tubes and ovaries (hysterectomy and bilateral salpingo-oophorectomy – please see separate leaflet) may be offered, this is usually reserved for women who have completed their family and is often a technically difficult procedure. The important points to consider with surgical treatments are that there is no guarantee of symptom relief even with these extensive operations; the complications associated with surgery; permanent loss of fertility with some surgeries (e.g. hysterectomy or removal of both ovaries); and the fact that current research suggests that approximately 35% of women will develop recurrence of their endometriosis after surgery and may consider further and repeated surgery. Repeated surgery for endometriosis excision is potentially more risky with increase possibility of serious complications.
Endometriosis and Fertility
The relationship between endometriosis and fertility is not yet fully established or understood. There are many women with endometriosis who become pregnant without difficulty, but endometriosis is found in 1 in 4 women who are undergoing investigations such as a laparoscopy for subfertility investigation (Cochrane 2002).
There are no preventative surgical treatments that have shown to be effective to improve future fertility, yet for those women who are having difficulties in getting pregnant; consultation with an infertility expert is initially needed for particular advice for treatment for endometriosis.
Cervical cancer is a type of cancer that starts in the cervix. The cervix is a hollow cylinder that connects the lower part of a woman’s uterus to her vagina. Most cervical cancers begin in cells on the surface of the cervix.
Many women with cervical cancer don’t realize they have the disease early on because it usually doesn’t cause symptoms until the late stages. When symptoms do appear, they’re easily mistaken for common conditions like menstrual periods and urinary tract infections (UTIs).
Typical cervical cancer symptoms are:
Most cervical cancer cases are caused by the sexually transmitted human papillomavirus (HPV). This is the same virus that causes genital warts.
There are about 100 different strains of HPV. Only certain types cause cervical cancer. The two types that most commonly cause cancer are HPV-16 and HPV-18.
Being infected with a cancer-causing strain of HPV doesn’t mean you’ll get cervical cancer. Your immune system eliminates the vast majority of HPV infections, often within 2 years.
HPV can also cause other cancers in women and men. These include:
HPV is a very common infection. Find out what percentage of sexually active adults will get it at some point in their lifetime.
Cervical cancer is very treatable if you catch it early. The four main treatments are:
Sometimes these treatments are combined to make them more effective.
The purpose of surgery is to remove as much of the cancer as possible. Sometimes the doctor can remove just the area of the cervix that contains cancer cells. For cancer that’s more widespread, surgery may involve removing the cervix and other organs in the pelvis.
Radiation kills cancer cells using high-energy X-ray beams. It can be delivered through a machine outside the body. It can also be delivered from inside the body using a metal tube placed in the uterus or vagina.
Chemotherapy uses drugs to kill cancer cells throughout the body. Doctors give this treatment in cycles. You’ll get chemo for a period of time. You’ll then stop the treatment to give your body time to recover.
Bevacizumab (Avastin) is a newer drug that works in a different way from chemotherapy and radiation. It blocks the growth of new blood vessels that help the cancer grow and survive. This drug is often given together with chemotherapy.
If we discovers precancerous cells in your cervix, they can be treated.
After you’ve been diagnosed, we will assign your cancer a stage. The stage tells whether the cancer has spread, and if so, how far it’s spread. Staging your cancer can help us recommend the right treatment for you.
Cervical cancer has four stages:
Causes of vaginal discharge
Vaginal discharge is a healthy bodily function resulting from natural changes in estrogen levels. The amount of discharge can increase from the likes of ovulation, sexual arousal, birth control pills, and pregnancy.
The color, smell, and texture of vaginal discharge can be adversely affected by changes to the vagina’s bacterial balance. That’s because when the number of harmful bacteria increases, vaginal infections are more likely.
Here are some of the possible infections to be aware of.
Bacterial vaginosis is a common bacterial infection. It causes increased vaginal discharge that has a strong, foul, and sometimes fishy odor. Discharge may also look gray, thin, and watery. In some cases, the infection produces no symptoms.
Although bacterial vaginosis isn’t transmitted via sexual contact, you have a higher risk of developing it if you’re sexually active or have recently gotten a new sexual partner. The infection can also put you at a higher risk of contracting a sexually transmitted infection (STI).
Trichomoniasis is another type of infection caused by a parasite. It’s usually spread by sexual contact, but can also be contracted by sharing towels or bathing suits.
Up to half of the people affected have no symptoms. Those who do will often notice a yellow, green, or frothy discharge with an unpleasant odor. Pain, inflammation, and itching around the vagina as well as when urinating or having sex are also common signs.
A yeast infection occurs when yeast growth increases in the vagina. It produces a thick and white discharge that looks similar to cottage cheese. This discharge doesn’t usually smell.
Other symptoms include burning, itching, and other irritation around the vagina along with soreness during sex or when urinating.
The following can increase your likelihood of yeast infections:
Gonorrhea and chlamydia are STIs that can produce an abnormal discharge due to infecting the cervix. It’s often yellow, greenish, or cloudy in color.
You may also experience:
But some people may have zero symptoms.
This STI can lead to thick vaginal discharge with a strong smell, particularly after sex. Sores and blisters lloking like a clod sore can appear around the genitals along with bleeding between periods and a burning sensation when urinating.
However, it’s more common to have no or mild symptoms. If symptoms do occur, you may experience repeated outbreaks throughout your life.
Heavy, foul-smelling discharge and pain in thelower abndomen, after sex, or while menstruating or urinating may be signs of pelvic inflammatory disease.
This occurs when bacteria move into the vagina and up to other reproductive organs and can be caused by STIs that are left untreated like chlamydia or gonorrhea.
The human papillomavirus infection is spread by sexual contact and can lead to cervical cancer. While there may be no symptoms, this type of cancer can result in:
In rare cases, brown or bloody discharge can also be a sign of endometrial cancer, fibroids, or other growths.
When to see a doctor or other healthcare professional
If you’re ever worried about your vaginal discharge, talk with a clinician as soon as possible. This is particularly true if your discharge changes color, smell, or consistency or if you’re noticing more of it than usual.
Other symptoms to watch out for include:
fever
pain in the abdomen or during penetrative vaginal sex
fatigue
increased urination
There are various contraception options available to help prevent pregnancy, and each method offers unique benefits and considerations. The choice depends on individual health, lifestyle, and personal preferences. Here’s an overview of the main types of contraception:
• Birth Control Pills: Daily pills that contain estrogen and progestin or progestin-only to prevent ovulation. Highly effective when taken consistently.
• Birth Control Patch: A skin patch worn on the body that releases hormones to prevent ovulation, replaced weekly for three weeks, with a patch-free week.
• Birth Control Injection (Depo-Provera): A progestin shot given every three months to stop ovulation.
• Birth Control Implant (Nexplanon): A small rod implanted under the skin of the upper arm, releasing progestin and effective for up to 3 years.
• Vaginal Ring (NuvaRing): A flexible ring inserted into the vagina monthly, releasing estrogen and progestin for three weeks.
• Hormonal IUDs (Mirena, Kyleena, Skyla, Liletta): Small T-shaped devices placed in the uterus that release progestin, effective for 3-6 years depending on the type.
• Copper IUD (ParaGard): A hormone-free IUD that uses copper to create an environment hostile to sperm, effective for up to 10 years.
• Condoms: Male and female condoms are placed over the penis or inside the vagina to block sperm. They are also the only method that protects against STIs.
• Diaphragm: A shallow, flexible cup inserted into the vagina to cover the cervix, used with spermicide for added effectiveness.
• Cervical Cap: Similar to a diaphragm but smaller, covering the cervix with spermicide for protection.
• Spermicide: Chemicals that kill sperm, used alone or with other methods like diaphragms and condoms.
• Includes IUDs and implants, which are highly effective, low-maintenance, and reversible methods that last for several years.
• Tubal Ligation (for women): Surgical procedure that blocks or cuts the fallopian tubes to prevent egg and sperm from meeting.
• Vasectomy (for men): Minor surgical procedure that cuts or seals the vas deferens, preventing sperm from entering semen.
• Morning-After Pill (Plan B, Ella): Pills taken up to 3-5 days after unprotected sex to prevent ovulation or fertilization.
• Copper IUD: Can be used as emergency contraception if inserted within five days after unprotected intercourse.
• Fertility Awareness: Tracking the menstrual cycle to avoid sex during fertile days.
• Withdrawal Method: Pulling out before ejaculation; less reliable as it depends on timing and self-control.
• Abstinence: Complete avoidance of sexual intercourse, which is the only method that is 100% effective.
• Combining methods, such as using condoms with birth control pills or IUDs, for added effectiveness and STI protection.
Menstrual abnormalities can result from a variety of factors that affect hormonal balance, reproductive organs, and overall health. Here are some common causes:
1. Hormonal Imbalances
• Estrogen and Progesterone Imbalances: These hormones regulate the menstrual cycle. Imbalances can disrupt ovulation, leading to irregular periods, heavy bleeding, or missed periods.
• Thyroid Disorders: Hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid) can impact menstrual cycle regularity, leading to heavier, lighter, or irregular bleeding.
• Prolactin: High levels of prolactin (a hormone produced by the pituitary gland) can interfere with menstrual cycles and cause amenorrhea (absence of menstruation).
2. Polycystic Ovary Syndrome (PCOS)
• PCOS is a common condition where the ovaries produce excessive androgens (male hormones), leading to irregular periods, anovulation (absence of ovulation), and sometimes heavy bleeding.
• It’s often associated with other symptoms such as acne, weight gain, and excessive body hair.
3. Uterine Fibroids and Polyps
• Fibroids: Noncancerous growths in or on the uterus, which can cause heavy and prolonged menstrual bleeding, pelvic pain, and anemia.
• Polyps: Small growths on the uterine lining that may lead to irregular or heavy bleeding between periods.
4. Endometriosis
• A condition where endometrial tissue (which normally lines the uterus) grows outside the uterus, often on the ovaries, fallopian tubes, or other pelvic organs.
• Endometriosis can cause heavy bleeding, severe menstrual cramps (dysmenorrhea), and irregular cycles.
5. Pelvic Inflammatory Disease (PID)
• An infection of the female reproductive organs, often caused by sexually transmitted infections (STIs).
• PID can lead to irregular periods, pain, and bleeding between periods.
6. Perimenopause
• The transition period before menopause, typically beginning in a woman’s 40s, when hormone levels start to fluctuate.
• This can lead to irregular cycles, lighter or heavier bleeding, and other symptoms such as hot flashes and mood swings.
7. Lifestyle Factors
• Stress: High levels of physical or emotional stress can disrupt the hypothalamus-pituitary-ovarian axis, leading to missed or irregular periods.
• Diet and Exercise: Extreme dieting, sudden weight loss, or excessive exercise can impact estrogen levels, causing irregular or missed periods (common in athletes and those with eating disorders).
• Obesity: Excess body fat can affect hormone balance, leading to irregular cycles and heavier bleeding.
8. Medications
• Certain medications, including hormonal contraceptives, anticoagulants, antipsychotics, and chemotherapy drugs, can influence menstrual cycles.
• Hormonal birth control can sometimes cause spotting, lighter periods, or, in some cases, stop menstruation altogether.
9. Chronic Health Conditions
• Diabetes and Insulin Resistance: These can impact menstrual regularity, especially in conditions like PCOS, which is often associated with insulin resistance.
• Celiac Disease: Malabsorption of nutrients due to untreated celiac disease can lead to hormonal imbalances, resulting in irregular periods.
10. Structural Issues and Congenital Abnormalities
• Conditions such as uterine septum, Asherman’s syndrome (scar tissue in the uterus), or other congenital reproductive tract abnormalities can cause irregular bleeding or difficulty menstruating.
11. Pregnancy and Related Complications
• Pregnancy can cause missed periods, and conditions like miscarriage or ectopic pregnancy can lead to irregular or unexpected bleeding.
12. Cancer
• Rarely, cancers of the reproductive system, such as uterine, ovarian, or cervical cancer, can cause abnormal bleeding, especially bleeding between periods or postmenopausal bleeding.
Cervical cancer screening is a preventive measure to detect abnormal cells in the cervix before they turn into cancer. It primarily involves two tests: the Pap smear (or Pap test) and the human papillomavirus (HPV) test. Regular screening helps catch changes early, reducing the risk of developing cervical cancer.
Key Cervical Cancer Screening Tests
1. Pap Smear (Pap Test)
• Detects abnormal cervical cells that may develop into cancer.
• Cells are collected from the cervix and examined for precancerous or cancerous changes.
• Recommended for women age <25 if screening deemed necessary.
2. HPV Test
• Identifies the presence of high-risk HPV types that can cause cervical cancer.
• Used alone or in combination with the Pap test for women 25 and older.
• When done with a Pap test (co-testing), it’s recommended every five years for women ages 25-60.
Screening Guidelines
• Ages <25: Screening of women younger than 25 years is not recommended but can also be individualized if a particular risk exist, in which case Pap test is the preferred test.
• Ages 25-60: Either, but HPV screening is preferred.k
• Pap test every three years, or
• HPV test alone every five years, or
• Co-testing (Pap and HPV together) every five years.
• Over 60: If there’s a history of regular, normal screening results, further screening may not be needed. Those with a history of cervical pre-cancer should continue screening for at least 20 years after the diagnosis.
Importance of Screening
Cervical cancer screening detects abnormal cells early, allowing for treatment before they develop into cancer. Screening is especially crucial as HPV, the main cause of cervical cancer, often has no symptoms and may persist unnoticed.
Preparing for the Test
• Avoid sexual intercourse, douching, or using vaginal products (like creams or tampons) 24-48 hours before the test.
• It’s ideal to schedule the test when you are not menstruating for clearer results.
Follow-Up for Abnormal Results
• Abnormal Pap Test: Follow-up may include a repeat test, HPV test, or a colposcopy (a detailed examination of the cervix).
• Abnormal HPV Test: Often followed by a colposcopy or additional testing to determine if treatment is needed.
Reducing Risk of Cervical Cancer
• HPV Vaccination: Recommended for pre-teens (ages 11-12) but can be given up to age 26, and in some cases, up to age 45.
• Safe Sexual Practices: Using condoms and limiting the number of sexual partners can reduce HPV transmission risk.
• Smoking Cessation: Smoking increases the risk of cervical cancer, especially in women with HPV.
Regular cervical cancer screening is one of the most effective ways to prevent cervical cancer and catch any cell changes early, allowing for timely treatment and improved outcomes.
Laparoscopy in Gynecology: Overview and Applications
Laparoscopy, also known as minimally invasive surgery (MIS) or keyhole surgery, is a surgical procedure that allows visualization and treatment of gynecological conditions using small incisions and a laparoscope (a thin tube with a camera). It has revolutionized gynecological care by reducing recovery times, pain, and complications compared to open surgery.
1. Indications for Laparoscopy in Gynecology
Laparoscopy is used for both diagnostic and therapeutic purposes.
• Pelvic pain of unclear origin: To investigate chronic pelvic pain, endometriosis, or pelvic inflammatory disease.
• Infertility workup: To assess tubal patency, adhesions, or endometriosis.
• Unexplained pelvic masses: To evaluate ovarian cysts or adnexal masses.
• Endometriosis treatment: Excision or ablation of endometrial implants and removal of adhesions.
• Ovarian cystectomy: Removal of ovarian cysts while preserving ovarian tissue.
• Ectopic pregnancy: Salpingostomy or salpingectomy.
• Hysterectomy: Laparoscopic-assisted vaginal hysterectomy (LAVH) or total laparoscopic hysterectomy (TLH).
• Myomectomy: Removal of uterine fibroids.
• Adhesiolysis: Treatment of pelvic adhesions.
• Tubal procedures: Tubal ligation, salpingectomy, or tubal reanastomosis.
2. Procedure Overview
• Preoperative evaluation (e.g., blood tests, imaging).
• Bowel preparation (if extensive surgery is anticipated).
• Informed consent detailing risks and benefits.
1. Anesthesia: General anesthesia is typically used.
2. Incisions: Small incisions (usually 5-10 mm) are made near the navel and lower abdomen.
3. Pneumoperitoneum: The abdominal cavity is inflated with carbon dioxide (CO₂) to create space.
4. Laparoscope Insertion: A camera and specialized instruments are inserted through the incisions.
5. Procedure Execution: The surgeon performs diagnostic or therapeutic interventions.
6. Closure: Instruments are removed, CO₂ is released, and the incisions are closed with sutures or adhesive.
• Smaller incisions and minimal scarring.
• Reduced postoperative pain.
• Shorter hospital stay and faster recovery.
• Lower risk of wound infections.
• Enhanced visualization of pelvic structures.
4. Risks and Complications
While laparoscopy is generally safe, potential complications include:
• Injury to surrounding structures: Such as bowel, bladder, or blood vessels.
• Bleeding: From vascular injury or organ trauma.
• Infection: At the incision site or within the abdomen.
• Gas-related issues: Shoulder pain due to CO₂ or subcutaneous emphysema.
• Anesthesia-related risks: Allergic reactions or respiratory complications.
• Hospital Stay: Most patients are discharged on the same day or within 24 hours.
• Pain Management: Mild analgesics are typically sufficient.
• Activity: Light activities can resume in 1-2 days, while full recovery may take 1-4 weeks depending on the procedure.
• Follow-up: Scheduled 1-2 weeks postoperatively for wound and symptom assessment.
1. Laparoscopic Hysterectomy: Complete or partial removal of the uterus.
2. Laparoscopic Myomectomy: For uterine fibroids, especially in women wishing to preserve fertility.
3. Endometriosis Surgery: Excision of implants and adhesions for pain relief and fertility improvement.
4. Salpingectomy or Salpingostomy: For ectopic pregnancy or sterilization.
5. Ovarian Cystectomy: Removal of ovarian cysts while preserving ovarian function.
6. Pelvic Adhesiolysis: For pain relief and restoring normal pelvic anatomy.
Laparoscopy is invaluable in diagnosing and treating infertility-related conditions:
• Tubal Factor Infertility: Identification and correction of tubal occlusion or damage.
• Endometriosis: Staging and removal of endometrial implants.
• Adhesions: Treatment of pelvic adhesions to improve conception chances.
8. Innovations in Gynecological Laparoscopy
• Robot-Assisted Laparoscopy: Improved precision and ergonomics using systems like the da Vinci Surgical System.
• Single-Port Laparoscopy: Further reduces scarring and recovery time.
• Advanced Imaging: Enhanced visualization with 3D and high-definition systems.
Conclusion
Laparoscopy is a cornerstone of modern gynecological practice, offering a minimally invasive approach to diagnosing and treating a wide range of conditions. Proper patient selection, skilled surgical technique, and meticulous postoperative care are key to optimizing outcomes.
If you’d like more details about a specific gynecological laparoscopic procedure, feel free to ask!
Vaginal thrush, also known as vulvovaginal candidiasis, is a common yeast infection caused by an overgrowth of Candida species, most commonly Candida albicans. It can cause significant discomfort but is generally not serious and can be effectively treated.
Symptoms
• Itching and irritation in the vagina and vulva.
• Thick, white, “cottage cheese-like” vaginal discharge.
• Redness and swelling of the vulva.
• Burning sensation, especially during urination or intercourse.
• Vaginal soreness or discomfort.
Risk Factors
• Antibiotic use (disruption of normal vaginal flora).
• Pregnancy (hormonal changes).
• Uncontrolled diabetes.
• Weakened immune system (e.g., HIV, corticosteroid use).
• Use of hormonal contraceptives.
• Tight or synthetic clothing that retains moisture.
Diagnosis
• Clinical history and examination: Assessment of symptoms and visual inspection.
• Microscopy and culture: Wet mount or gram staining may reveal budding yeasts and pseudohyphae. Culture can confirm Candida species if needed.
Treatment
1. Topical Antifungal Creams or Pessaries
• Examples: Clotrimazole, Miconazole.
• Duration: 3 to 7 days, depending on the preparation.
2. Oral Antifungals
• Example: Fluconazole 150 mg as a single dose.
• Consider longer courses for recurrent infections.
3. Recurrent Thrush Management
• Definition: ≥4 episodes in a year.
• Long-term suppressive therapy (e.g., weekly Fluconazole for 6 months) may be needed.